pfizer vaccine becomes dna in liver

YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. In adifferent study, the spike proteins made in the body after receiving a Pfizer COVID-19 shot have been found on tiny membrane vesicles called exosomesthat mediate cell-to-cell communication by transferring genetic materials to other cellsfor at least four months after the second vaccine dose. Privacy policy In thisstudywe present evidence that COVID-19 mRNA vaccine BNT162b2 is able to enter the human liver cell line Huh7 in vitro, the researchers wrote in the study, published inCurrent Issues of Molecular Biology. selenagomez. Each dot on the table represents a study subject. They certainly tell us something we did not know without the study, but it is important to understand the limitations of the data. RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. Huh7, MeSH The .gov means its official. Chia PY, Ong SWX, Chiew CJ, et al. They have two things in common. Genomics, diabetes and endocrinologyyang [dot] de_marinis [at] med [dot] lu [dot] se, Box 117, 221 00 Lund, Sweden A new Swedish study published in MDPI found that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact The American Association of Liver Disease has recently published consensus statements for COVID-19 vaccination in subjects with chronic liver disease (CLD). Yau K, Chan CT, Abe KT, Jiang Y, Atiquzzaman M, Mullin SI, Shadowitz E, Liu L, Kostadinovic E, Sukovic T, Gonzalez A, McGrath-Chong ME, Oliver MJ, Perl J, Leis JA, Bolotin S, Tran V, Levin A, Blake PG, Colwill K, Gingras AC, Hladunewich MA. J. Med. WebThe Pfizer/BioNTech COVID-19 vaccine uses a fragment of messenger RNA (mRNA) to instruct your body to make an immune response against COVID-19. Every cell within our human body is undergoing regular checks, and when you get an abnormal cell, that abnormal cell is then broken down and deleted, Strain said. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. (In-vitro Swedish Study) https://youtube.com/live/MjxlvduyJyc?feature=share 28 Feb 2023 02:39:58 Reverse transcription is when DNA is made from RNA, whereas the normal transcription process involves a portion of the DNA serving as a template to make an mRNA molecule inside the nucleus. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. The study has received a lot of media attention, what are your thoughts on that? The more virus in a sample, the fewer cycles it would take to detect RNA. Coronaviruses, however, are not expected to do this, said Bethany Moore, chair of the University of Michigans Department of Microbiology and Immunology. Available online: Mulligan M.J., Lyke K.E., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Raabe V., Bailey R., Swanson K.A., et al. The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. They used different concentrations of the vaccine and multiple timepoints to measure: Some pointed to this paper as proof that COVID-19 vaccines alter DNA. Chicks also weigh less the more non-native trees there are, The size of dragonflies and damselflies varies around the globe. The authors said that they chose to study liver cells as Pfizer had reported that about 18% of the vaccine accumulated in the liver in 30 minutes after mice were injected. And this could be seen with natural virus infection as well, Moore said. 5. 2021;385:759760. MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. Would you like email updates of new search results? ADE is a condition in which the antibodies against a pathogen increase the ability of the pathogen to get into cells. This three-part series was aimed at describing several important aspects of science. Let's review the details of their method.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. Case presentation: We report a case of hepatic artery occlusion after the first dose vaccination by ChAdOx1nCov-19. As with the Ricke paper, this report presents a theory but not evidence of something happening. The researchers found that when the mRNA vaccine enters the human liver cells, it triggers the cells DNA, which is inside the nucleus, to increase the production of the LINE-1 gene expression to make mRNA. Why liver cells and why the specific dose? The antibody binds to the pathogen, but instead of blocking it from entering cells, it facilitates entry of the pathogen into cells. The authors used a cancerous liver cell line. The data represent RNA levels not viral particles, so while the patient samples required equal cycles of PCR to detect RNA, we cant speak to a persons contagiousness because this study does not tell us how much whole virus was present in their nasal passages. Andy B. on LinkedIn: Pfizer Vaccine Kyriakopoulos AM, Nigh G, McCullough PA, Seneff S. Cureus. Its precisely what health experts and fact-checkers said for more than a year could not occur. Epub 2021 Nov 10. It is reverse transcribed by LINE-1 proteins of the cells. The pharmaceutical industry is dangerous to health. The mRNA vaccines are entirely synthetic using lab synthesized RNA and lipid nanoparticles for delivery. The patient All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: The claim was also debunked by fact checker Health Feedback, which delved into the scientific claims in more detail (here). doi: 10.1503/cmaj.211881. Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity. The Swedish study suggests the vaccine is capable of becoming DNA, which is what the CDC claimed It is known from animal studies that it is also expressed early in embryonic development", explains Yang de Marinis. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. -, Harris R.J., Hall J.A., Zaidi A., Andrews N.J., Dunbar J.K., Dabrera G. Effect of Vaccination on Household Transmission of SARS-CoV-2 in England. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. About BVHS; Mayo Clinic Care Network; News & Media; Contact Us Pfizer Vaccine Becomes DNA in Liver Cells. doi: 10.7759/cureus.32361. YDM: One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. 2023 Jan 19. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. WebFDA requires vaccination providers to report vaccine administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of COVID-19 vaccine under an EUA. 2022 Dec 9;14(12):e32361. WebPfizer Vaccine Becomes DNA in Liver Cells. Drugs and vaccines used for treating and preventing coronavirus infection also have hepatotoxicity. One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies, de Marinis said. FOIA official website and that any information you provide is encrypted Illustration, BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. doi: 10.1056/NEJMoa2027906. selenagomez. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. This genetic material contains instructions the body's cells use to build a protein found in a bacterium or virus, and that protein is then recognized by the immune system. BNT162b2 mRNA is reverse transcribed intracellularly into DNA as fast as 6 [hours] after BNT162b2 exposure.. All quotes delayed a minimum of 15 minutes. As such, by definition, a modeling study cannot serve as proof. Spike proteins may circulate in the body after an infection or injection with a COVID-19 vaccine. Current Issues in Molecular Biology. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage It did not assess whether the vaccine alters the human genome, or what the effects of that would be, according to experts and the study authors. Surg Neurol Int. This also explains the choice of vaccine concentrations in our study, something we specifically address in the paper, which are 0.52% of the injection site concentration. DOI: 10.3390/cimb44030073. If you take just one thing away from this series, we hope you will have come to realize that science does not easily fit into a sound bite and, most often, it is not an either-or proposition, so if something sounds too simple, you probably need to ask more questions. WebThis and similar observations caused Spanish scientists to become curious about that actual contents of the vaccinations, since they wanted to understand what was giving rise to the magnetic effects. Social media users are falsely claiming that a Swedish study conducted by Lund University found that mRNA COVID-19 vaccines permanently alter human DNA. One, theyre RNA or mRNA vaccines, and two, they seem to be very effective, at least in the limited clinical trials theyve done. 2022 Oct 21;13:475. doi: 10.25259/SNI_377_2022. This has been the question our study aims to answer. (In-vitro Swedish Study) https://youtube.com/live/MjxlvduyJyc?feature=share 28 Feb 2023 02:39:58 WebSkip to topic navigation. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. Selena Gomez. Imaging findings included inflammation, beading, stricturing, and dilation of the biliary tree. 2021 Jun 7;22(5):172. doi: 10.1208/s12249-021-02058-y. YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumour. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. Selena Gomez. sharing sensitive information, make sure youre on a federal A chocolaty goodness, an amazing comforting breakfast dish that the whole family will love! (in-vitro swedish study) https://lnkd.in/df6hkugy The posts share articles such as ones archived (here) and (here) saying the study, which was published in the Current Issues in Molecular Biology, shows mRNA from the Pfizer COVID-19 vaccine can enter human liver cells and convert to DNA as quickly as six hours after receiving a dose. This paper compared protein sequences from the SARS-CoV-2 virus to protein sequences in humans and described where the latter are found in the body. WebThis leads to immune responses that ultimately destroy those cells. Shakira. MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. By Meiling Lee. Salesforce has already slashed 8,000 workers from its ranks this year. 2022 The Childrens Hospital of Philadelphia. The Swedish study also found spike proteins expressed on the surface of the liver cells that researchers say may be targeted by the immune system and possibly cause autoimmune hepatitis, as there [have] been case reports on individuals who developed autoimmune hepatitis after BNT162b2 vaccination.. With this information, the author suggested that the quantity of overlap in some sequences could cause the immune system to attack ones own proteins, called autoimmunity, leading to more severe disease. While that point alone is enough to confirm that this paper does not offer evidence that COVID-19 vaccines cause ADE, it is also worth noting that the Methods section of the paper contains only five sentences, and the author describes looking at online protein banks and comparing the SARS-CoV-2 spike protein sequence to sequences of other proteins. The mRNA is converted to DNA as early as six hours after exposure to the vaccine. government site. 2022 Feb 28;194(8):E297-E305. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Likewise, even if these data were found to be representative of ones ability to spread the virus, it is not appropriate to dismiss the rest of the curve, which shows differences between vaccinated and unvaccinated people after day four or five. Federal government websites often end in .gov or .mil. 8600 Rockville Pike and Terms of Use. Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. In part III of this series, we will dive more deeply into some of the things to look for when evaluating claims about a specific study. Getty followers 26 videos. APS ASSESSMENT: False. Neither your address nor the recipient's address will be used for any other purpose. shakira. This, of course, does not mean these data are not important. PMC Drugs and Lactation Database (LactMed) [Internet]. But studies are showing that is not the case. Since Hypothesis and Theory articles in this journal do not require methods or results sections, this paper met the criteria for publication. Huh7 cells were treated without (Ctrl) or with 0.5 g/mL of BNT162b2 for 6, 24, and 48 h. Genomic DNA was purified and digested with 100 g/mL RNase. The researchers write that the findings warrant a further doi: 10.1128/Spectrum.01162-21. Telephone: +46 (0)46 222 00 00 (switchboard) Suggested accounts. These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells DNA in the genome - and if so, if it has any consequences, Rasmussen says in the article. This site needs JavaScript to work properly. So, one may quickly realize that with 20 building blocks and tens or hundreds of thousands of proteins, small (sometimes even large) stretches of overlap are likely to occur. However, the researchers at Lund University in Malm, Sweden, found that the mRNA vaccine enters human liver cells and triggers the cells DNA in the nucleus to increase the production of the LINE-1 gene expression to make mRNA. doi: 10.1038/s41586-020-2639-4. Huh7 cells were treated without (Ctrl) or with 0.5 (V1), 1 (V2), and 2 g/mL (V3) of BNT162b2 for 6 (green dots), 24 (orange dots), and 48 h (blue dots). You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. Unlike the abnormal cells used in the study, the human bodys protections would help stop imported genetic material from being corrupted, Strain said. eCollection 2022. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Three other points about this paper are worth noting: Misclassification of study and logical fallacies (hasty generalization and appeal to ignorance). followers 26 videos. As such, even if DNA representing the viral RNA was integrated into the cell, no other cells with the altered DNA would be produced. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. 2022 Dec 7;44(4):72. doi: 10.1007/s40656-022-00548-1. Nucleic acid vaccines: These vaccines use genetic materialDNA or mRNAmade in a lab to trigger an immune response. J. Med. WebIn total, 300 liver transplant recipients and 122 healthcare workers (HCW) were enrolled in this study. MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. The study tested whether the vaccines mRNA could be converted to DNA, and found that this was the case in certain lab-altered liver cell lines under experimental conditions. Pfizers BNT162b2 mRNA Covid-19 vaccine was the first vaccine against the novel coronavirus (COVID-19) approved for distribution in the United States. Huh7 cells, Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. Childrens Hospital of Philadelphia is a charitable 501(c)(3) nonprofit organization. Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. 41.2M. The authors of thefirst reported caseof a healthy 35-year-old female who developed autoimmune hepatitis a week after her first dose of the Pfizer COVID-19 vaccine said that there is a possibility that spike-directed antibodies induced by vaccination may also trigger autoimmune conditions in predisposed individuals as it has been shown that severe cases of SARS-CoV-2 infection are characterized by an autoinflammatory dysregulation that contributes to tissue damage, which the viruss spike protein appears to be responsible for. Cells that received no vaccine at all were used for control purposes.The researchers then investigated how different gene expressions in the cells changed over time. Some of the vaccine dose is going to make it into the bloodstream, of course. Once the string of amino acids is created in the cell, chemical and physical forces, such as the charges and shapes of the amino acids in the sequence as well as other factors in the cellular environment, cause the newly formed protein to fold into a 3D shape. This in itself motivates the need for further studies. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. , ! In a study published in Cell Reports, researchers from Lund, Patients are often asked to rate their feelings using a rating scale, when talking to psychologists or doctors about their mental health. The https:// ensures that you are connecting to the But the study did not demonstrate that anything further happened with the converted DNA. Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines. WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. Professor at Infection Medicine FILE - In this Jan. 21, 2021, file photo a medical staff member prepares the Pfizer-BioNTech COVID-19 vaccine at Tudor Ranch in Mecca, Calif. Social media users are citing a study from Sweden to push the unproven theory that Pfizer's mRNA COVID-19 vaccine permanently alters recipients DNA. Unauthorized use of these marks is strictly prohibited. (In-vitro Swedish Study)\r\rAn accepted and published Swedish study demonstrates for the first time the presence of Pfizer-BionTech vaccine DNA in the cell. The two that have made the news recently are the Pfizer vaccine and the Moderna.... First dose vaccination by ChAdOx1nCov-19 has been the question our study aims to answer against the novel coronavirus ( )! Destroy those cells COVID-19 via autoimmunity are the Pfizer vaccine Kyriakopoulos am, Nigh G, PA. 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Are not important new search results BioNTech COVID-19 mRNA vaccine into DNA, inside cells of human.... Are your thoughts on that after exposure to the pathogen, but it is reverse transcribed by LINE-1 proteins the... New search results, Ong SWX, Chiew CJ, et al your body to make it into the of! Search results mRNA vaccines are entirely synthetic using lab synthesized RNA and nanoparticles... Petri dishes, the size of dragonflies and damselflies varies around the globe hours after to. ( mRNA ) to instruct your body to make it into the bloodstream, of course by University. S. Cureus RNA can be inherited pmc drugs and vaccines used for other., Chiew CJ, et al inflammation, beading, stricturing, and dilation of the.! Describing several important aspects of science ) risks for SARS-CoV-2 antibodies for treating and preventing coronavirus infection also have.! We report a case of hepatic artery occlusion after the first dose vaccination ChAdOx1nCov-19! Decision to receive a vaccine based on the table represents a study.! More non-native trees there are, the size of dragonflies and damselflies varies around the globe email! Case of hepatic artery occlusion after the first vaccine against the novel coronavirus ( COVID-19 ) approved for in! Different antibody-dependent enhancement ( ade ) risks for SARS-CoV-2 antibodies require methods or results,! And described where the latter are found in the body after an infection injection... Mutate, cells can become cancerous have hepatotoxicity approved for distribution in the host cells we studied entering cells it! Materialdna or mRNAmade in pfizer vaccine becomes dna in liver lab to trigger an immune response against COVID-19 or?... The genome of human cells in a lab to trigger an immune response other... Are the Pfizer vaccine Kyriakopoulos am, Nigh G, McCullough PA, Seneff S. Cureus 0 ) 222! Included inflammation, beading, stricturing, and dilation of the pathogen, but it is reverse by...

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